A pharmaceutical clinical production application required both cGMP conditions and OEB 5 operator protection as high potency solids were being used in the process. The Fitzpatrick Company’s Contained Compaction System CCS320 was selected by the customer for the dry granulation operation stage due to its ability to achieve the desired capacity and particle size distribution. Although the CCS achieves OEB 3 & 4 containment levels with an on-board PCS system, in order to enhance the safety levels and reach OEB 4 & 5, further design solutions were needed.