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Solid Dosage Form Manufacture via Twin Screw Extrusion

The application of continuous extrusion via twin screw extruders (TSE) for pharmaceutical solid dosage form production is growing in popularity as a preferred option to more traditional granulation techniques. The TSE offers several advantages as a method of granulation formation including continuous processing with reproducibility and combination of a variety of process steps within one piece of equipment, i.e. distributive and dispersive mixing, granulating and devolatilization. The production method provides gentle product handling at short residence time and low temperature. Two methods in which the extruder is used for solid dosage form production are wet granulation and hot melt extrusion.